Mitomycin C–Induced DNA Damage in Fanconi Anemia: Cross-Linking or Redox-Mediated Effects?
نویسنده
چکیده
and Granulocyte Immunobiology, S’Agaró, Girona, Spain, May 9-12, 1998, p 52 (abstr) 6. Hessner MJ, Curtis BR, Endean DJ, Aster RH: Determination of neutrophil antigen NA gene frequencies in five different ethnic groups by the polymerase chain reaction with sequence-specific primers (PCR-SSP). Transfusion 36:895, 1996 7. Lin M, Chen CC, Wang CL, Lee HL: Frequencies of neutrophilspecific antigens among Chinese in Taiwan. Vox Sang 66:247, 1994 (letter)
منابع مشابه
DNA Damage in Leukocytes from Fanconi Anemia (FA) Patients and Heterozygotes Induced by Mitomycin C and Ionizing Radiation as Assessed by the Comet and Comet-FISH Assay
Background: Lymphocytes of Fanconi anemia (FA) show an increased sensitivity to the alkylating agents such as mitomycin C (MMC), but their responses to gamma-irradiation is controversial. The extent of DNA damage in leukocytes of FA patients following irradiation and MMC treatment was studied at cellular and single chromosome level. Methods: DNA damage induced by gamma-rays and MMC was measure...
متن کاملMitomycin C-induced DNA damage in Fanconi anemia: cross-linking or redox-mediated effects?
and Granulocyte Immunobiology, S’Agaró, Girona, Spain, May 9-12, 1998, p 52 (abstr) 6. Hessner MJ, Curtis BR, Endean DJ, Aster RH: Determination of neutrophil antigen NA gene frequencies in five different ethnic groups by the polymerase chain reaction with sequence-specific primers (PCR-SSP). Transfusion 36:895, 1996 7. Lin M, Chen CC, Wang CL, Lee HL: Frequencies of neutrophilspecific antigens...
متن کاملMitomycin C–Induced DNA Damage in Fanconi Anemia: Cross-Linking or Redox-Mediated Effects?
and Granulocyte Immunobiology, S’Agaró, Girona, Spain, May 9-12, 1998, p 52 (abstr) 6. Hessner MJ, Curtis BR, Endean DJ, Aster RH: Determination of neutrophil antigen NA gene frequencies in five different ethnic groups by the polymerase chain reaction with sequence-specific primers (PCR-SSP). Transfusion 36:895, 1996 7. Lin M, Chen CC, Wang CL, Lee HL: Frequencies of neutrophilspecific antigens...
متن کاملMitomycin C–Induced DNA Damage in Fanconi Anemia: Cross-Linking or Redox-Mediated Effects?
and Granulocyte Immunobiology, S’Agaró, Girona, Spain, May 9-12, 1998, p 52 (abstr) 6. Hessner MJ, Curtis BR, Endean DJ, Aster RH: Determination of neutrophil antigen NA gene frequencies in five different ethnic groups by the polymerase chain reaction with sequence-specific primers (PCR-SSP). Transfusion 36:895, 1996 7. Lin M, Chen CC, Wang CL, Lee HL: Frequencies of neutrophilspecific antigens...
متن کاملThe Fanconi anemia complementation group C protein corrects DNA interstrand cross-link-specific apoptosis in HSC536N cells.
Fanconi anemia (FA) cells are hypersensitive to cytotoxicity, cell cycle arrest, and chromosomal aberrations induced by DNA cross-linking agents, such as mitomycin C (MMC) and nitrogen mustard (HN2). Although MMC hypersensitivity is complemented in a subset of FA cells (complementation group C [FA-C]) by wild-type FAC cDNA, the cytoprotective mechanism is unknown. In the current study, we teste...
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